OHCHR visit to a detention centre, Nepal. UN Photo / Robert Few or experts appointed as members (hereinafter referred to as “members”), and the circumstances surrounding the body’s establishment and conduct will vary each time. While existing standards and best practices provide a solid framework to guide the work of commissions and missions, flexibility, good judgement and adaptability will be required, as every commission/mission will in some way be unique and require specific responses and support. While the guidance is based primarily on the experience of United Nations fact-finding and investigative bodies, it is also intended to assist other organizations, including regional organizations, in the establishment and management of similar international bodies. 2. TARGET AUDIENCE The guidance is mainly intended for use by members of commissions/missions, staff of such bodies, States, civil society organizations and United Nations departments that may be involved in advocating, mandating, establishing, supporting and resourcing such bodies. It is also directed at national human rights institutions, academic institutions and others who may be involved in these activities. 4 COMMISSIONS OF INQUIRY AND FACT-FINDING MISSIONS ON INTERNATIONAL HUMAN RIGHTS AND HUMANITARIAN LAW